Coronavirus Newsletter Links - April

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Welcome to the first of our Covid-19 Specials. There is a lot of information available, thousands of scientific papers, 100s of pages from all kinds of august institutions, all of which have application and data... but some are more useful than others. The CBRNe World team has skimmed through the vast majority of these pages and looked for those that, in their judgement, are a cut above the rest, that the information delivered is either provided in such a way that it is more obviously applicable, or it will benefit the widest spread of our responder community.

There is a lot of 'page one' information that has not been included, from the WHO, CDC, ECDC etc., as we assume that this will, rightly, be the first port of call for many people. Each month we will try and find sites away from the beaten track that deserve greater viewing. If you have a favourite that you would like to be included please contact the editor This email address is being protected from spambots. You need JavaScript enabled to view it. 

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Top Tips

These are the pages that we found that are most obviously useful/practical to a wide variety of people.

Dr Christina Baxter is always reliable and has a wide variety of practical information for first responders
https://emergencyresponsetips.com/papers  

The Centre for Evidence-Based Medicine at Oxford University has done a great job peer reviewing various scientific papers and providing expert insight and fact checking. Before you start going through NLM or other scientific paper sites come here first... 
https://www.cebm.net/covid-19/

The Institute for Health Metrics and Evaluation is predicting Covid peak dates in each US state based on hospital bed-days, ICU-days, ventilator days and deaths in the next 4 months
https://covid19.healthdata.org/projections

There is a LOT of misinformation being provided by social media, the EU versus Disinformation site is useful for debunking media reports
http://euvsdisinfo.eu/

Moving at light speed the European Union has funded 18 research projects into Covid. Interested agencies are urged to get in touch and extract information on epidemiology, modelling, diagnostics, and treatments
https://ec.europa.eu/info/sites/info/files/research_and_innovation/research_by_area/documents/ec_rtd_cv-projects.pdf 

Realtime Threat Map

Protection

The protection URLs before provide useful information on respiratory and dermal protection - especially the surgical mask efficacy debate.

Webinar: Optimization Strategies for Healthcare Personal Protective Equipment     https://emergency.cdc.gov/coca/calls/2020/callinfo_032520.asp

Personal Protective Equipment Burn Rate Calculator, spreadsheet-based model that provides information for healthcare facilities to plan and optimize the use of PPE
https://www.cdc.gov/coronavirus/2019-ncov/hcp/ppe-strategy/burn-calculator.html

Protective effect of surgical masks on flu aerosols
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591312/

Further thoughts on the efficacity of rudimentary forms of respiratory protection 
https://medium.com/@Cancerwarrior/covid-19-why-we-should-all-wear-masks-there-is-new-scientific-rationale-280e08ceee71

UK advice on surgical face mask vs FFP3 https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/874411/When_to_use_face_mask_or_FFP3.pdf

Decon of disposable respiratory protection
https://www.cdc.gov/coronavirus/2019-ncov/hcp/ppe-strategy/decontamination-reuse-respirators.html

OSHA interim guidance for specific worker groups, including deathcare workers
https://www.osha.gov/SLTC/covid-19/controlprevention.html#deathcare

Mitigation/Decon

This section looks at reducing the contamination on surfaces and what governmental strategies there have been to try and reduce the impact of the pandemic.

How will country-based mitigation measures influence the course of the COVID-19 epidemic
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30567-5/fulltext

Report on the Global Impact of COVID-19 and Strategies for Mitigation and Suppression from Imperial College London https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College-COVID19-Global-Impact-26-03-2020v2.pdf

Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents https://www.sciencedirect.com/science/article/pii/S0195670120300463

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1
https://www.nejm.org/doi/10.1056/NEJMc2004973

EPA-registered disinfectant products that have qualified for use healthcare and business use against SARS-CoV-2 https://www.epa.gov/pesticide-registration/list-n-disinfectants-use-against-sars-cov-2

CDC guidelines for healthcare facilities with confirmed Covid patients 
https://www.cdc.gov/coronavirus/2019-ncov/community/organizations/cleaning-disinfection.html

Decontamination of N95 and Powered‐Air Purifying Respirators (PAPRs)
https://www.safety.duke.edu/sites/www.safety.duke.edu/files/N95%20Decontamination%20Procedure.pdf

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Diagnostics

Information on what is working, or not, in terms of improving identification and detection of Covid.

WHO guidance to labs involved in testing patients
https://www.who.int/publications-detail/laboratory-testing-for-2019-novel-coronavirus-in-suspected-human-cases-20200117

Link to all current FDA Emergency Use Authorisations, including PPE, medical devices, diagnostic tests and therapeutics https://www.fda.gov/emergency-preparedness-and-response/mcm-legal-regulatory-and-policy-framework/emergency-use-authorization#2019-ncov

Information from the CDC on testing for COVID with PCR, intended for labs and points of care
https://www.fda.gov/media/134922/download

Evaluation of a PCR laboratory-developed test for the detection of SARS-CoV-2
https://eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.9.2000152

Tips for diagnosing Covid in a patient and some thoughts on state of the art https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1745095

Germany leads Europe in their diagnostics, this paper goes into detail on their laboratory experiences with the novel real-time RT-PCR assays comparing different one-step PCR systems and a commercial kit, using a Bio-Rad CFX 96 cycler https://eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.9.2000173

Guidance for industry on evaluation procedures for companies selling diagnostic products
https://www.gov.uk/government/publications/covid-19-evaluation-of-commercially-available-diagnostic-products/guidance-for-industry-on-evaluations-of-diagnostic-products-for-coronavirus-covid-19

Long list of companies involved in Covid diagnostics
https://www.finddx.org/covid-19/pipeline/

Co-infection with other viruses might influence the rRT-PCR test accuracy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082661/

Inability of airport screening to detect Covid carriers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014668/

Therapeutics

What medical countermeasures (including vaccines) are being developed and what existing treatments are showing promise for therapeutics.

Assessment of Evidence for COVID-19-Related Treatments: American Society of Health-Systems Pharmacists https://www.ashp.org/-/media/assets/pharmacy-practice/resource-centers/Coronavirus/docs/ASHP-COVID-19-Evidence-Table.ashx

A review of some therapeutics for Covid, including Remdesivir and Chloroquine and hydroxychloroquine https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofaa105/5811022 fbclid=IwAR3tD1hRrUz_x4FDylM085ElHzlVK0QaCTYZjS_W1Kt4GPCeAom7QbKrb5c

Analysis of some of the recent trials of chloroquine and hydroxychloroquine
https://www.cebm.net/covid-19/chloroquine-and-hydroxychloroquine-current-evidence-for-their-effectiveness-in-treating-covid-19/

WHO Publication and guidance on off-label use of medicines for COVID-19
https://www.who.int/news-room/commentaries/detail/off-label-use-of-medicines-for-covid-19

A rapid Canadian review of effectiveness and safety of antiviral or antibody treatments for coronavirus
https://www.medrxiv.org/content/10.1101/2020.03.19.20039008v2

Information on the various countermeasures currently going through trials
https://www.cebm.net/covid-19/registered-trials-and-analysis/

A paper on the R&D of therapeutic agents and vaccines for COVID-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094090/

Overview of the vaccine work for Covid
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094941/

Strategy

Information for national and regional emergency planners. 

WHO’s Infection prevention and control strategies, many useful files for a wide variety of government departments
https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/infection-prevention-and-control

An analysis from a Chinese school of public health on the impact of government interventions https://onlinelibrary.wiley.com/doi/10.1002/jmv.25750

Healthcare planning resources and many useful tools, including pharmacy calculator and ensuring staff retention post Covid
https://asprtracie.hhs.gov/COVID-19

US National Strategy documents, risk and severity assessment tools
https://www.cdc.gov/flu/pandemic-resources/national-strategy/index.html

A variety of plans from the WHO on Strategic preparedness and response
https://www.who.int/publications-detail/strategic-preparedness-and-response-plan-for-the-new-coronavirus

Variety of UK guidance for health professionals
https://www.gov.uk/government/publications/wuhan-novel-coronavirus-infection-prevention-and-control

International Association of Fire Chiefs guide for Coronavirus planning and response
https://www.iafc.org/docs/default-source/1ems/covid-response-and-planning-recommendations.pdf

Tactics

Information for a wide variety of responders - from clinicians and health workers, through to other kinds of first responders. Practical sites/information to improve response or save lives. 

A series of practical guides from the WHO for states to develop a Covid response plan
https://www.who.int/docs/default-source/coronaviruse/covid-19-sprp-unct-guidelines.pdf?sfvrsn=81ff43d8_4

Information for businesses in getting your workplace ready for COVID-19
https://www.who.int/docs/default-source/coronaviruse/getting-workplace-ready-for-covid-19.pdf?sfvrsn=359a81e7_6

Lots of useful videos from the WHO for a wide variety of practitioners in a range of languages
https://openwho.org/channels/covid-19  

COVID-19 responder self-triage to monitor exposure to traumatic stress
https://www.health.state.mn.us/communities/ep/behavioral/triage.pdf

Estimating the infection and case fatality ratio based on age-adjusted data from the Diamond Princess https://eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.12.2000256

A paper predicting Covid outbreaks based on internet searches and social media
https://eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.10.2000199

UK guidance for (non-health) first responders
https://www.gov.uk/government/publications/novel-coronavirus-2019-ncov-interim-guidance-for-first-responders/interim-guidance-for-first-responders-and-others-in-close-contact-with-symptomatic-people-with-potential-2019-ncov

US guidance for law enforcement/first responders
https://www.cdc.gov/coronavirus/2019-ncov/community/guidance-law-enforcement.html

Guidance for emergency call handlers on Covid
https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-for-ems.html

New AI finds changes in three features—levels of the liver enzyme alanine aminotransferase (ALT), reported myalgia, and hemoglobin levels were most accurately predictive of subsequent, severe disease
http://techscience.com/cmc/v63n1/38464

Tips for individuals having to deal with queries from the public/press on Covid
https://www.astho.org/COVID-19/Q-and-A/

Education and training modules that can include CE
https://netec.org/training-2/

Covid hospital resource planning toolkit, algorithms, screening and first steps
https://www.massgeneral.org/disaster-medicine/tools/

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