Coronavirus Newsletter Links - May

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Welcome to the second of our Covid-19 Specials. Even in the space of a month the information available seems to have doubled! We have not bothered with any of the opinion pieces that the media is generating, though there is value there, instead we have skimmed through hundreds of practical or scientific papers that have valuable application and data. Below is what we consider to be a cut above the rest, that the information delivered is either provided in such a way that it is more obviously applicable, or it will benefit the widest spread of our responder community.

There is a lot of 'page one' information that has not been included, from the WHO, CDC, ECDC etc., as we assume that this will, rightly, be the first port of call for many people. Each month we will try and find sites away from the beaten track that deserve greater viewing. If you have a favourite that you would like to be included please contact the editor This email address is being protected from spambots. You need JavaScript enabled to view it. 

Epishuttle

Top Tips -

A weekly review of interesting Covid stories - https://naturemicrobiologycommunity.nature.com/users/17778-ben-johnson/posts/64014-the-covid-19-compendium

International directory of guidelines and best practice recommendations documents for the care and management of COVID-19. https://www.ersnet.org/covid-19-guidelines-and-recommendations-directory

What’s working for Covid-19 patients. Vital information from the front lines - https://journals.lww.com/em-news/blog/BreakingNews/pages/post.aspx?PostID=508

All kinds of good ideas in here and updated weekly. It’s FEMA’s Community Innovation stories and covers first response and the wider community.  https://www.fema.gov/media-library/assets/documents/187266

Not a tip per se, but an interesting Covid ‘grand mystery’ out of the many others available… https://www.cebm.net/covid-19/covid-19-the-widow-of-hampstead-revisited/

No-Fear is a EC funded project that brings together a pan-European and beyond network of emergency medical care practitioners, suppliers, decision and policy makers. They are running a series of webinars with practitioners talking about Covid. Often worth a listen – www.no-fearproject.eu/

Mortality and Morbidity Weekly Report from CDC often has interesting bits, like the increase in calls to poison centres thanks to over-use, and lack of understanding, of disinfectants -https://www.cdc.gov/mmwr/Novel_Coronavirus_Reports.html  

The Hazmat Guys are always worth a listen, and they have partnered with Dr Christina Baxter for Covid information - https://thehazmatguys.com/thmg234-covid-19-update-with-dr-christina-baxter/

And if you want a laugh, have a look at some of the Covid myths that the WHO needs to ‘bust’ - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public/myth-busters  

tex sheild

Protection

CDC slide pack for facilities lacking appropriate PPE and needing to improvise. Useful advice - https://www.cdc.gov/coronavirus/2019-ncov/downloads/hcp/emergency-considerations-ppe-508.pptx

Gowns vs aprons in a clinical setting - https://www.cebm.net/covid-19/what-is-the-effectiveness-of-protective-gowns-and-aprons-against-covid-19-in-primary-care-settings/

OSHA guidance on the reuse of filtering facepiece respirators (FFRs) that have been decontaminated through certain methods - https://www.osha.gov/memos/2020-04-24/enforcement-guidance-decontamination-filtering-facepiece-respirators-healthcare

OSHA on use of respiratory protection equipment certified under standards of other countries, or, in other words, understanding whether that Asian or South American N95 you bought would meet standards… https://www.osha.gov/memos/2020-04-03/enforcement-guidance-use-respiratory-protection-equipment-certified-under

In more Baxter news, by the time you read this Emergency Response TIPS should have released a new web-based class “Validating Respiratory Protection for Infectious Disease Response.” With so many fake products being churned out it’s vital to make sure that what you are buying does the job - https://emergencyresponsetips.com/

Once you know whether the PPE works, and conforms to recognised standards, the AHRMM have a useful site tracking vetted non-traditional suppliers. https://www.ahrmm.org/ahrmm-covid-19

Unsure whether face masks should be worn or not? Useful information assessing the various reports and studies - https://erj.ersjournals.com/content/early/2020/04/27/13993003.01260-2020?cct=2283

Comparing PPE recommendations for health care professionals from a variety of major entities - https://erj.ersjournals.com/content/early/2020/04/27/13993003.01260-2020?cct=2283

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Mitigation/Decon

EPA Expands Research on SARS-CoV-2 in the Environment, Webinar, Wed, May 27, 2020 7:00 PM - 8:00 PM BST. https://register.gotowebinar.com/register/1297620939911049228

The NIAID have verified methods that do, and do not, work for decontaminating N95 respirators for re-use. https://www.medrxiv.org/content/10.1101/2020.04.11.20062018v2

The method that they like ois VHP, and more information on a novel process for N95 Respirator disinfection with Vaporized Hydrogen Peroxide can be found here - https://www.journalacs.org/article/S1072-7515(20)30349-5/pdf

Practical ECDC Guidelines for the use of non-pharmaceutical measures to delay and mitigate the impact of Covid https://www.ecdc.europa.eu/sites/default/files/documents/novel-coronavirus-guidelines-non-pharmaceutical-measures_0.pdf

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Diagnostics

Review of the sensitivity and specificity of the tests that are currently in use for the detection of SARS-CoV-2 https://www.medwave.cl/link.cgi/English/Reviews/GeneralReviews/7891.act

Great explainer for four of the most common diagnostics for Covid. https://www.cebm.net/covid-19/what-tests-could-potentially-be-used-for-the-screening-diagnosis-and-monitoring-of-covid-19-and-what-are-their-advantages-and-disadvantages/

Not sure which diagnostic you should be using where? FIND has a range of user test cases, and estimated costings to help - https://www.finddx.org/covid-19/dx-use-cases/

Understanding the problems behind antibody testing - https://www.idsociety.org/globalassets/idsa/public-health/covid-19/idsa-covid-19-antibody-testing-primer.pdf

Detailed protocols for expressing the antigen for serological assays, as well as setting up ELISA - https://currentprotocols.onlinelibrary.wiley.com/doi/full/10.1002/cpmc.100

Development of a rapid (<40 min), easy-to-implement, accurate CRISPR–Cas12-based lateral flow assay - https://www.nature.com/articles/s41587-020-0513-4

Serologic assays for detection of SARS-CoV-2 neutralizing, spike protein–specific, and nucleocapsid-specific antibodies. https://wwwnc.cdc.gov/eid/article/26/7/20-0841_article

Potential of saline, phosphate buffered saline and minimum essential medium for your PCR viral transport needs - https://jcm.asm.org/content/jcm/early/2020/03/27/JCM.00590-20.full.pd

Therapeutics

Review of the trials of Hydroxychloroquine for Covid - https://www.cebm.net/covid-19/hydroxychloroquine-for-covid-19-what-do-the-clinical-trials-tell-us/

In addition to remdesivir, there are other anti-virals that are showing promise - https://stm.sciencemag.org/content/12/541/eabb5883.short   

Botulinum Toxin as a therapeutic for Covid?? - https://www.sciencedirect.com/science/article/pii/S2590098620300294?via%3Dihub

Assessment of Evidence for COVID-19-Related Treatments (Updated) - https://www.ashp.org/-/media/assets/pharmacy-practice/resource-centers/Coronavirus/docs/ASHP-COVID-19-Evidence-Table.ashx

Information on the various types of Covid treatment around the world (updated) - https://www.who.int/publications-detail/covid-19-landscape-of-experimental-treatments

Biofire

Strategy

Examples of comprehensive pandemic plans - https://files.asprtracie.hhs.gov/documents/aspr-tracie-ta-sample-state-pandemic-plans-3-17-2020.pdf

CDC’s COVID-19Surge is a spreadsheet-based tool that hospital administrators and public health officials can use to estimate the surge in demand for hospital-based services - https://www.cdc.gov/coronavirus/2019-ncov/hcp/COVIDSurge.html  

Early and quick identification of the potential risk zones of COVID-19 infection in megacities for implementing targeted infection prevention and control measures - https://www.sciencedirect.com/science/article/pii/S0048969720325122?via%3Dihub

What policy makers need to know about COVID-19 protective immunity -  https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(20)30985-5.pdf

The need to prepare for a wave of suicide attempts, especially as business comes online -  https://www.thelancet.com/pdfs/journals/lanpsy/PIIS2215-0366(20)30144-9.pdf

COVID-19 planning tools, including another hospital planning tool and estimates and forecasts
https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/covid-19-planning-tools/

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Tactics

Lessons learned from setting up drive through testing - https://files.asprtracie.hhs.gov/documents/aspr-tracie-ta-drive-through-testing-3-16-2020.pdf

Recommendations for preventing or managing COVID-19 anxiety in Clinicians (and other responders) - https://www.cebm.net/covid-19/practical-tips-for-clinicians-helping-patients-with-covid-related-anxiety-distress/

Lots of really good ‘Clinical Operations Pearls’ in here and a wide variety of expertise - https://files.asprtracie.hhs.gov/documents/aspr-tracie-covid-19-clinical-experience-from-the-field-final.pdf

All kinds of training modules being offered for free by the American Society of Health-System Pharmacists - http://elearning.ashp.org/COVID-19

Re-organising healthcare to ensure that preventable conditions don’t enter hospital - https://www.cebm.net/covid-19/what-conditions-could-we-prioritise-in-the-primary-care-setting-to-reduce-non-covid-related-admissions-to-hospital/

A 10-step guide to convert a surgical unit into a COVID-19 unit, based on Italian experience - https://www.sciencedirect.com/science/article/pii/S1743919120303514

Simulation to identifying system errors and latent safety hazards in response to preparation for the expected COVID-19 surge. https://www.cureus.com/articles/31308-covid-19-outbreak-response-for-an-emergency-department-using-in-situ-simulation

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